
In honor of the CTN’s 10th anniversary, the
Journal of Substance
Abuse Treatment presents “A Decade of Research by the National Drug
Abuse Treatment Clinical Trials Network.”
This special supplement features overview articles describing the
completed studies and outcomes from the past decade of CTN research. It
also reviews several ancillary investigations, where data from original
CTN protocols is examined in a new way to reveal new correlations and
propose future research.
Five articles in the issue are
co-authored by researchers and clinicians from the Pacific Northwest
node of the CTN, where the Alcohol and Drug Abuse Institute serves as the Regional Research Training Center (RRTC):
Ron Jackson, from Evergreen Treatment Services,
cowrote “The First Decade of the National Drug Abuse
Treatment Clinical Trials Network: Bridging the Gap Between Research
and Practice to Improve Drug Abuse Treatment,” which reviews
the rationale for the CTN, describes the translation of its guiding
principles into research endeavors, and anticipates the future evolution
of clinical research within the Network.
In “Study Results from the Clinical Trial Network’s
First 10 Years: Where Do They Lead?” Elizabeth (Betsy)
Wells, Don Calsyn and Dennis Donovan
from ADAI, Andrew Saxon from the VA Puget Sound, and Ron
Jackson from Evergreen Treatment Services, review the
completed (to date) protocols in the CTN with the aim of identifying the
incremental progress toward improving drug treatment made by these
trials.
“From Research to the Real World: Buprenorphine in
the Decade of the Clinical Trials Network,” was co-written by Andrew
Saxon of the VA Puget Sound, and reviews the 6 CTN
buprenorphine protocols (CTN-0001/2, 0003, 0010, 0027, 0030), describing
related efforts to overcome challenges to the implementation of
buprenorphine therapy in mainstream practice.
Jessica DiCenzo from Recovery Centers of King
County, a PN Node CTP, was co-author for “Predicting Outpatient Treatment Entry Following
Detoxification for Injection Drug Use: The Impact of Patient and Program
Factors.” This secondary analysis of data from CTN-0017
examined variables predicting outpatient treatment entry within six
months of residential detoxification.
And finally, Don Calsyn from ADAI co-authored “Multisite Effectiveness Trials of Treatments for
Substance Abuse and Co-Occurring Problems: Have We Chosen the Best
Designs?“ This article systematically examines, for each of
the completed CTN protocols, the experimental design type chosen and its
original rationale, the main findings of the trials, and the strengths
and weaknesses of the design in hindsight.
Congratulations to all our Pacific Northwest Node authors!
Find these articles and all the others from the JSAT special
supplement in the CTN Dissemination Library.