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Combination Therapy for Alcohol Dependence
The first article presenting outcomes from NIAAA's multi-center COMBINE study has been published in the May 3, 2006 issue of Journal of the American Medical Association (JAMA). The University of Washington was one of the participating COMBINE sites, led by ADAI director Dennis M. Donovan, Ph.D.
The efficacies of medication and behavioral therapies, alone or in combination, for treating alcohol dependence were assessed in the multicenter randomized Combined Pharmacotherapies and Behavioral Interventions (COMBINE) study, in which study participants were randomly assigned to 1 of 9 treatment groups. Anton and colleagues report that patients in all groups had an increased number of days of abstinence. However, patients receiving naltrexone, CBI, or both along with medical management had more days of abstinence and fewer heavy drinking days than patients in other treatment groups. [See also the NIAAA press release].
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